Supplemental Intraoperative Oxygen and Long-term Mortality: Subanalysis of a Multiple Crossover Cluster Trial
نویسندگان
چکیده
Background Whether supplemental oxygen worsens long-term mortality remains unclear, with contradictory trial results. The authors therefore tested the hypothesis that (80% vs. 30%) increases hazard for mortality. Methods conducted a post hoc analysis of large multiple crossover cluster in which more than 5,000 colorectal surgeries on 4,088 adults were allocated to receive either 30% or 80% inspired during general anesthesia. assessed effect versus target-inspired and calculated Kaplan–Meier survival estimates. Analysis was restricted patients home address Ohio because could obtain reliable vital status information from Department Health (Columbus, Ohio) them. Results A total 3,471 qualifying performed 2,801 analyzed, including 1,753 (51%) 1,577 given 1,718 1,551 oxygen. observed incidence death after median 3 yr 13% (234 1,753) group 14% (245 1,718) group. estimated ratio 0.94 (95% CI, 0.78 1.13; P = 0.493). Conclusions In this large, controlled trial, did not increase postoperative Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2021
ISSN: ['0003-3022', '1528-1175']
DOI: https://doi.org/10.1097/aln.0000000000003694